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KMID : 0376219790160010065
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Chonnam Medical Journal
1979 Volume.16 No. 1 p.65 ~ p.75
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Synergy of carbenicillin and sulbenicillin combined with gentamicin and tobramycin against Pseudomonas aeruginosa
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Abstract
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Fifty-four strains of Pseudomonas aeruginosa were submitted to the synergistic activity test of carbenicillin (CB) and sulbenicillin (SB) combined with gentamicin (GM) or tobramycin (TM).
The minimum inhibitory concentration (MIC) of each drug and drugs combined in various ratios was measured by- checkerboard dilution method. The synergism of the antibiotics against each organism was determined through analysing the MIC- distribution curve on isobologram and calculating the fractional inhibition concentration index (FICI).
MICs of GM, TM, CB; and-SB-against the 54 test strains were distributed from 0.65mg/ml through 40mg/ml, from 2.54mg/ml through 40mg/ml, from 10mg/ml through 80mg / ml, and from 2.5mg/ml through 40mg/ml, respectively.
The strains which were inhibited synergistically by all of the four drug combinations (GM ? CB, GM ? SB, TM ? CB, TM ? SB) were 13 in number (24%), while only 2 strains showed negative response (3.7%).
Other responses worthy of notice were that 8 strains showed negative to GM ?SB combination among 33 ones which reacted to the synergistic effect by GM ? CB; 9 strains were negative to GM? CB among 34 ones which were positive to GM ? SB; 26 strains were positive to TM .CB, being negative at the same time to TM ?SB, while only 5.strains were negative to TM ? CB, being positive to TM ? SB.
It was unpredictable, however, if the degree of resistance of an organism to any single antibiotic action had a significant effect on the organism´s response to the activity of antibiotics combined, even though there was observed a rather contrasting tendancy that strains showing resistance to a single drug reacted more sensitively to the inhibitory action of drugs combined.
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